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KMID : 0032219890010010059
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Annals of Dermatology
1989 Volume.1 No. 1 p.59 ~ p.59
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Adverse Reaction to Methotrexate and Etretinate in a Patient with Psoriasis
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임이석:Lim Ee-Seok
김명남:Kim Myeung-Nam/노병인:Ro Byung-In/장진요:Chang Chin-Yo
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Abstract
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A 49-year-old Caucasian male patient suffered from fever general weakness and diffuse hair loss on the scalp for 3 days. Skin lesions showed erythematous scaly patches with pustules and erosions on the lower extremities and perianal region, and multiple ulcerations on the labial mucoas. A complete blood cell count revealed thrombocytopenia and leukopenia, which gradually worsened day after day (platelet: 29, 000/mm2, WBC: 1,000/mm3). Candida albicans was isolated from the lesions of the oral cavity and lower extremities.
Twelve days prior to the visit, he had taken etretinate Tegison®) P.O.25mg/day, prednisolone P.O. 50mg1dy and methotrexate P.O. 15mg/day for 5 days for the treatment of psoriasis.
We presume that these adverse reactions may be synergistic adverse reactions, probably due to methotrexate and etretinate in consideration of the patient’s history.
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KEYWORD
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Adverse reaction, Etretinate, Methotrexate, Psoriasis
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